By Nicolle Sitte, Thomas von Zglinicki (auth.), Thomas von Zglinicki (eds.)

During the final forty years, the research of the organic foundation of getting older has stepped forward greatly, and it has now turn into an self sufficient and decent box of research and learn. the fundamental explanation for getting older is molecular harm that slowly overwhelms mobile and organismic security, fix and upkeep structures. in recent times, a wealth of hugely subtle study has remodeled this concept from a reputable speculation not just to an immense concept, yet basically to accredited wisdom. getting older on the Molecular point examines the major parts during this transformation.
Bringing jointly contributions from a world staff of authors, this quantity should be of curiosity to graduates and postgraduates within the fields of drugs and nursing, researchers of alternative points of biogerontology and people within the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.

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Radial Res. 16: 487-502. Swallow AJ (1960). Effect of ionizing radiation on proteins, RCO groups, peptide bond cleavage, inactivation, -SH oxidation In: AJ Swallow, ed. Radiation Chemistry of Organic Compounds. New York: Pergamon Press, pp. 211-24. Schuessler H, Schilling K (1984). Oxygen effect in radiolysis of proteins. Part 2. Bovine serum albumin. lnl J Radial Bioi. 45: 267-81. Huggins TG, Wells-Knecht MC, Detorie NA, Baynes JW, Thorpe SR (1993). Formation of a-tyrosine and dityrosine in proteins during radiolytic and metal-catalyzed oxidation.

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40. Bandaru V, Sunkara S, Wallace SS, Bond JP (2002). A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII. DNA Repair (Arnst) 1: 517-29. 41. Rosenquist TA, Zaika E, Fernandes AS, Zharkov DO, Miller H, Grollman AP (2003). The novel DNA glycosylase, NEILl, protects mammalian cells from radiation-mediated cell death. DNA Repair (Arnst) 2: 581-91. Oxidative Damage to Proteins Nicolle Sitte Department of Anaesthesiology and Critical Care Medicine, CHARITE- University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany Introduction Protein oxidation in vivo is a natural consequence of aerobic life.

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